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Hideaki Bujo Selected Research

Lecithin Cholesterol Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency)

7/2021Current Status of Familial LCAT Deficiency in Japan.
1/2020Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT.
9/2018Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis.
11/2016A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously.
1/2016Gene-manipulated Adipocytes for the Treatment of Various Intractable Diseases.
8/2014Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency.
5/2013Amelioration of circulating lipoprotein profile and proteinuria in a patient with LCAT deficiency due to a novel mutation (Cys74Tyr) in the lid region of LCAT under a fat-restricted diet and ARB treatment.
10/2011Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations.
3/2011Fibrin glue increases the cell survival and the transduced gene product secretion of the ceiling culture-derived adipocytes transplanted in mice.
2/2011Disturbed apolipoprotein A-I-containing lipoproteins in fish-eye disease are improved by the lecithin:cholesterol acyltransferase produced by gene-transduced adipocytes in vitro.

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Hideaki Bujo Research Topics

Disease

15Atherosclerosis
12/2016 - 04/2002
14Coronary Artery Disease (Coronary Atherosclerosis)
08/2022 - 04/2002
13Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
08/2022 - 02/2002
10Lecithin Cholesterol Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency)
07/2021 - 02/2011
9Alzheimer Disease (Alzheimer's Disease)
02/2019 - 08/2004
7Xanthomatosis (Xanthoma)
06/2022 - 01/2012
7Hypercholesterolemia
09/2018 - 01/2003
7Insulin Resistance
09/2010 - 09/2004
6Hypertriglyceridemia
09/2022 - 01/2003
5Cardiovascular Diseases (Cardiovascular Disease)
08/2022 - 01/2012
5Inborn Genetic Diseases (Disease, Hereditary)
05/2022 - 01/2004
5Type 2 Diabetes Mellitus (MODY)
11/2016 - 09/2004
4Dyslipidemias (Dyslipidemia)
02/2021 - 01/2004
4Atherosclerotic Plaque (Atheroma)
05/2020 - 06/2006
4Weight Loss (Weight Reduction)
01/2018 - 09/2004
4Hypoxia (Hypoxemia)
01/2016 - 04/2008
3Hypertension (High Blood Pressure)
05/2022 - 01/2004
3Proteinuria
07/2021 - 10/2011
3Corneal Opacity
07/2021 - 10/2011
3Coronary Disease (Coronary Heart Disease)
02/2021 - 02/2002
3Neoplasms (Cancer)
12/2016 - 01/2015
3Diabetic Retinopathy (Retinopathy, Diabetic)
08/2014 - 04/2008
3Body Weight (Weight, Body)
01/2013 - 12/2008
3Cognitive Dysfunction
01/2013 - 01/2012
3Obesity
02/2009 - 05/2007
2Carotid Artery Diseases
06/2022 - 02/2002
2Mucocutaneous Lymph Node Syndrome (Kawasaki Disease)
01/2022 - 03/2016
2Renal Insufficiency (Renal Failure)
07/2021 - 08/2014
2Anemia
07/2021 - 05/2013
2Epiretinal Membrane (Epiretinal Membranes)
05/2017 - 08/2014
2Retinal Perforations
05/2017 - 08/2014
2Frontotemporal Dementia (Semantic Dementia)
01/2015 - 01/2012
2Stable Angina
11/2014 - 01/2013
2Hyperplasia
04/2014 - 01/2005
2Leukemia
04/2014 - 10/2012
2Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
03/2014 - 10/2013
2Metabolic Syndrome (Dysmetabolic Syndrome X)
12/2008 - 06/2008
2Glucose Intolerance
05/2007 - 09/2004
2Diabetes Mellitus
05/2007 - 01/2004
1Pancreatitis
09/2022
1Bacterial Infections (Bacterial Infection)
10/2021
1Sepsis (Septicemia)
10/2021
1Sitosterolemia
05/2020
1Pre-Eclampsia (Preeclampsia)
10/2019
1Triple Negative Breast Neoplasms
01/2019
1Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
09/2018
1Breast Neoplasms (Breast Cancer)
01/2018
1Rhinosinusitis
10/2017

Drug/Important Bio-Agent (IBA)

16oxidized low density lipoproteinIBA
06/2022 - 02/2002
14Biomarkers (Surrogate Marker)IBA
01/2022 - 07/2012
13LipidsIBA
08/2022 - 01/2004
12Lipoproteins (Lipoprotein)IBA
08/2022 - 02/2002
12LDL Receptors (LDL Receptor)IBA
05/2020 - 01/2004
11LDL CholesterolIBA
06/2022 - 02/2002
11HDL CholesterolIBA
05/2022 - 04/2002
9Triglycerides (Triacylglycerol)IBA
09/2022 - 04/2002
8LDL Lipoproteins (beta Lipoproteins)IBA
06/2022 - 01/2004
8Proteins (Proteins, Gene)FDA Link
01/2016 - 02/2007
6Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)IBA
09/2018 - 02/2011
6LigandsIBA
01/2018 - 03/2014
5EnzymesIBA
10/2021 - 02/2011
5Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2020 - 10/2006
5Amyloid (Amyloid Fibrils)IBA
02/2019 - 02/2007
4Probucol (Lorelco)FDA Link
06/2022 - 12/2008
3HDL LipoproteinsIBA
02/2021 - 01/2012
3CholesterolIBA
01/2020 - 01/2004
3Glucose (Dextrose)FDA LinkGeneric
06/2016 - 09/2004
3Malondialdehyde (Propanedial)IBA
10/2015 - 04/2002
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2008 - 11/2006
2ApolipoproteinsIBA
08/2022 - 08/2004
2Pharmaceutical PreparationsIBA
05/2022 - 12/2008
2AntioxidantsIBA
02/2021 - 12/2008
2Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
01/2019 - 01/2018
2Immunoglobulin G (IgG)IBA
10/2017 - 11/2016
2Lipoprotein Lipase (Diacylglycerol Lipase)IBA
01/2017 - 01/2012
2AntibodiesIBA
11/2016 - 10/2016
2Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA
12/2015 - 08/2004
2Amino AcidsFDA Link
01/2015 - 01/2003
2Retinaldehyde (Retinal)IBA
06/2014 - 04/2008
2Urokinase Plasminogen Activator ReceptorsIBA
03/2014 - 04/2013
2Messenger RNA (mRNA)IBA
04/2013 - 04/2008
2Advanced Glycation End ProductsIBA
09/2010 - 05/2007
2Insulin (Novolin)FDA Link
09/2010 - 09/2004
2CytokinesIBA
04/2007 - 03/2007
2low density lipoprotein inhibitorIBA
01/2004 - 04/2002
1Apolipoproteins E (ApoE)IBA
09/2022
1Lipoprotein(a)IBA
08/2022
1Apolipoproteins B (ApoB)IBA
07/2021
1campesterolIBA
05/2020
1gamma-sitosterol (beta-sitosterol)IBA
05/2020
1SterolsIBA
01/2020
1Interleukin-6 (Interleukin 6)IBA
10/2019
1Apolipoprotein E4IBA
02/2019
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2019
1Neuregulin-1 (Neuregulin 1)IBA
01/2018
1histidine-rich proteinsIBA
01/2018

Therapy/Procedure

9Therapeutics
07/2021 - 02/2009
3Percutaneous Coronary Intervention
05/2020 - 01/2013
2Secondary Prevention
02/2021 - 06/2016
1Renal Dialysis (Hemodialysis)
07/2021